Clues to Vip Function from Knockout Mice.
From: Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794-8172, USA. sami.i.said@stonybrook.edu
Annals of the New York Academy of Sciences
- Publish Date: Jul 2006
- ISSN: 0077-8923
- Volume: 1070
- Issue:
- Pages: 5-9
- Medium: Print
- Language: English
- Citation (JAMA): Hamidi S A, Szema A M, Lyubsky S, et al. Clues to Vip Function from Knockout Mice.. Ann. N. Y. Acad. Sci. Jul 2006;1070:5-9
Abstract
We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.
Mesh Headings (Keywords): Animals, Bronchitis, Disease Susceptibility, Endotoxemia, Female, Lipopolysaccharides, Male, Methacholine Chloride, Mice, Mice, Inbred C57BL, Mice, Knockout, Survival Rate, Vasoactive Intestinal Peptide
Check for Full Text / PubMed Unique Identifier (PMID): 16888146
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