A Splice Variant to Pacap Receptor That is Involved in Spermatogenesis is Expressed in Astrocytes.
From: Department of Molecular Genetics and Biochemistry, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Dr. Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, Tel Aviv University, Tel Aviv 69978, Israel.
Annals of the New York Academy of Sciences
- Publish Date: Jul 2006
- ISSN: 0077-8923
- Volume: 1070
- Issue:
- Pages: 484-90
- Medium: Print
- Language: English
- Citation (JAMA): Pilzer Inbar, Gozes Illana, et al. A Splice Variant to Pacap Receptor That is Involved in Spermatogenesis is Expressed in Astrocytes.. Ann. N. Y. Acad. Sci. Jul 2006;1070:484-90
Abstract
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor, PAC1, recognizes PACAP with a higher affinity than it recognizes vasoactive intestinal peptide (VIP) and belongs to the subfamily G protein-coupled receptors. So far, more than 10 different splice variants of PAC1 have been cloned from rat tissue. Interestingly, the various PAC1 splice variants exhibit different signaling pathways. These splice variants are suggested to play a functional role mostly in the brain as well as in the testes. The present article introduces PAC1(3a) that was originally discovered in testes as another potential regulator in rat astrocytes.
Mesh Headings (Keywords): Animals, Astrocytes, Base Sequence, Brain, Cells, Cultured, Exons, Male, Mice, Molecular Sequence Data, RNA Splicing, Rats, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I, Spermatogenesis, Variation (Genetics)
Check for Full Text / PubMed Unique Identifier (PMID): 16888214
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