Benazepril Combined with Either Amlodipine or Hydrochlorothiazide is More Effective Than Monotherapy for Blood Pressure Control and Prevention of End-organ Injury in Hypertensive Dahl Rats.
From: Nephrology Section, VA Medical Center, Renal Division, Miller School of Medicine, and Vascular Biology Institute, University of Miami, Miami, Florida, USA.
Journal of cardiovascular pharmacology
- Publish Date: Jul 2006
- ISSN: 0160-2446
- Volume: 48
- Issue: 1
- Pages: 857-61
- Medium: Print
- Language: English
- Citation (JAMA): Zhou Ming-Sheng, Jaimes Edgar A, Raij Leopoldo, et al. Benazepril Combined with Either Amlodipine or Hydrochlorothiazide is More Effective Than Monotherapy for Blood Pressure Control and Prevention of End-organ Injury in Hypertensive Dahl Rats.. J. Cardiovasc. Pharmacol. Jul 2006;48:857-61
Abstract
We studied the effect of hydrochlorothiazide (HCTZ), the angiotensin-converting enzyme inhibitor benazepril, the calcium channel blocker amlodipine, or a combination of benazepril/amlodipine or benazepril/HCTZ on systolic blood pressure (BP) and end-organ injury (left ventricular hypertrophy, proteinuria, and endothelium-dependent relaxation to acetylcholine) in hypertensive Dahl salt-sensitive rats fed either a normal-salt (0.5% NaCl) or high-salt (4% NaCl) diet for 6 weeks. Rats fed a high-salt diet developed hypertension and significant end-organ injury. Monotherapy with HCTZ (75 mg/L in drinking water) or amlodipine (10 mg/kg/day by gavage) reduced systolic BP and proteinuria; benazepril (40 mg/kg/day by gavage) decreased proteinuria without significantly lowering systolic BP. In rats receiving a high-salt diet, only HCTZ reduced left ventricular hypertrophy, whereas endothelium-dependent relaxation was improved by amlodipine and benazepril but not by HCTZ. Combining benazepril with either amlodipine or HCTZ dramatically reduced systolic BP and end-organ injury. These data clearly support clinical studies suggesting that combination therapy is more effective than monotherapy for systolic BP control and prevention of end-organ injury. Complementary mechanisms of action of agents from different antihypertensive classes appear to facilitate the greater benefit on BP and end-organ injury.
Mesh Headings (Keywords): Acetylcholine, Administration, Oral, Amlodipine, Animals, Antihypertensive Agents, Benzazepines, Blood Pressure, Drug Therapy, Combination, Hydrochlorothiazide, Hypertension, Male, Rats, Rats, Inbred Dahl, Sodium Chloride, Dietary, Vasodilation
Check for Full Text / PubMed Unique Identifier (PMID): 16891915
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