Sexual Dimorphism in Insulin Sensitivity and Susceptibility to Develop Diabetes in Rats.
From: Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico.
The Journal of endocrinology
- Publish Date: Aug 2006
- ISSN: 0022-0795
- Volume: 190
- Issue: 2
- Pages: 425-32
- Medium: Print
- Language: English
- Citation (JAMA): Vital Paz, Larrieta Elena, Hiriart Marcia, et al. Sexual Dimorphism in Insulin Sensitivity and Susceptibility to Develop Diabetes in Rats.. J. Endocrinol. Aug 2006;190:425-32
Abstract
The goal of this study was to evaluate gender-related differences of some metabolic determinants of insulin sensitivity and of susceptibility to the effects of diabetes. Changes in body weight, blood glucose, and serum insulin concentrations were compared between female and male Wistar rats in prepubertal, pubertal, and adult stages of life. A diabetic model was induced by streptozotocin (STZ) under nicotinamide protection in both sexes and metabolic patterns were evaluated during the next 4 weeks. Finally, the pancreases were processed for morphometric analysis. In the three age groups, at similar blood glucose levels, higher fasting serum insulin levels were found in female as compared with age matched male rats. After STZ treatment, female rats show lower insulin and higher glucose levels, and a worse survival rate as compared with male rats. The more severe disease phenotype observed in female animals is associated with a more dramatic perturbation of pancreatic islet morphology. Significant differences exist in insulin sensitivity between sexes, females being less sensitive to insulin than males at all age groups and more susceptible to the rapid development of a more severe form of diabetes than males.
Mesh Headings (Keywords): Animals, Biological Markers, Blood Glucose, Body Composition, Diabetes Mellitus, Experimental, Disease Susceptibility, Female, Glucagon, Glucose Tolerance Test, Immunohistochemistry, Insulin, Insulin Resistance, Islets of Langerhans, Male, Microscopy, Confocal, Niacinamide, Rats, Rats, Wistar, Sex Characteristics
Check for Full Text / PubMed Unique Identifier (PMID): 16899575
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.