Tgfbeta Type Ii Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves.
From: Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.
The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publish Date: Aug 2006
- ISSN: 1529-2401
- Volume: 26
- Issue: 33
- Pages: 8417-27
- Medium: Internet
- Language: English
- Citation (JAMA): D'Antonio Maurizio, Droggiti Anna, Feltri M Laura, et al. Tgfbeta Type Ii Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves.. J. Neurosci. Aug 2006;26:8417-27
Abstract
During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo. Here, we tested whether the type II transforming growth factor (TGF) beta receptor has a role in this process. We generated a conditional knock-out mouse in which the type II TGFbeta receptor is specifically ablated only in Schwann cells. Inactivation of the receptor, evident at least from embryonic day 18, resulted in suppressed Schwann cell death in normally developing and injured nerves. Notably, the mutants also showed a strong reduction in Schwann cell proliferation. Consequently, Schwann cell numbers in wild-type and mutant nerves remained similar. Lack of TGFbeta signaling did not appear to affect other processes in which TGFbeta had been implicated previously, including myelination and response of adult nerves to injury. This is the first in vivo evidence for a growth factor receptor involved in promoting Schwann cell division during development and the first genetic evidence for a receptor that controls normal developmental Schwann cell death.
Mesh Headings (Keywords): Animals, Animals, Newborn, Axotomy, Cell Death, Cell Proliferation, Cells, Cultured, Down-Regulation, Drug Synergism, Embryo, Mammalian, Embryonic Development, Mice, Mice, Knockout, Myelin Sheath, Nerve Crush, Nerve Tissue Proteins, Neuregulin-1, Protein-Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Schwann Cells, Sciatic Nerve, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 16914667
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.