Circulating Endothelial Progenitor Cells Correlate with Erectile Function in Patients with Coronary Heart Disease.
From: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany. magnus@baumhaekel.de
European heart journal
- Publish Date: Sep 2006
- ISSN: 0195-668X
- Volume: 27
- Issue: 18
- Pages: 2184-8
- Medium: Print
- Language: English
- Citation (JAMA): Baumhäkel Magnus, Werner Nikos, Böhm Michael, et al. Circulating Endothelial Progenitor Cells Correlate with Erectile Function in Patients with Coronary Heart Disease.. Eur. Heart J. Sep 2006;27:2184-8
Abstract
AIMS: The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED). EPC play a major role in repair mechanisms of the endothelial monolayer, but the role of EPC in ED is unclear. METHODS AND RESULTS: Circulating levels of CD34(+)/KDR(+) and CD133(+) EPC were determined in 119 patients with known coronary artery disease. ED was evaluated with an ED-score generated from the KEED questionnaire. Prevalence of ED was 59.7%. In univariate analysis, age, hypertension, reduced left ventricular ejection fraction (LVEF), diabetes, and circulating levels of CD133(+) EPC, but not cardiovascular drug treatment were associated with ED. Body mass index (BMI) was positively (r = 0.319, P=0.003) and high-density lipoprotein was negatively (r=-0.246, P=0.034) correlated with ED. Adjustment for age, diabetes, hypertension, BMI, smoking, LVEF, use of statins and lower urinary tract symptoms, and prior coronary intervention revealed low levels of circulating immature CD133(+) EPC as independent risk factor for ED (95% CI -11.183 to -1.7371, P=0.008). CONCLUSION: Reduced levels of circulating CD133(+) EPC are an independent risk factor for ED. Thus, EPC may be a link between cardiovascular risk factors, endothelial dysfunction, and ED.
Mesh Headings (Keywords): Adult, Aged, Aged, 80 and over, Cell Count, Coronary Disease, Endothelial Cells, Endothelium, Vascular, Humans, Impotence, Vasculogenic, Male, Middle Aged, Risk Factors, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16926179
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.