Effect of Mongolian Plants on in Vivo Insulin Action in Diabetic Rats.
From: Department of Health Science, Faculty of Psychological and Physical Science, Aichi Gakuin University, 12 Araike, Nisshin 470-0195, Japan.
Diabetes research and clinical practice
- Publish Date: Feb 2007
- ISSN: 0168-8227
- Volume: 75
- Issue: 2
- Pages: 135-40
- Medium: Print
- Language: English
- Citation (JAMA): Khookhor Oyun, Bolin Qin, Oshida Yoshiharu, et al. Effect of Mongolian Plants on in Vivo Insulin Action in Diabetic Rats.. Diabetes Res. Clin. Pract. Feb 2007;75:135-40
Abstract
In the present study, we firstly performed a preliminary investigation on the acute effect of Mongolian medicinal plant extracts (Dryopteris species, Aspidiaceae) on the glucose tolerance in rats, evaluated by an oral glucose tolerance test (OGTT). Then, we investigated the effect of the same extracts on in vivo insulin action in streptozotocin (50 mg kg(-1) BW, i.v.)-induced diabetic rats by means of the euglycemic clamp. In diabetic rats, the glucose metabolic clearance rate (MCR) during 3.0 (low-dose) and 30.0 mU kg(-1)min(-1) (high-dose) insulin infusion was significantly higher in animals administered with plant extracts (500 mg kg(-1) BW, p.o.), compared with saline-administered animals (low-dose — normal control: 16.3+/-0.7 ml kg(-1)min(-1) versus plant extract 1: 15.8+/-0.6 ml kg(-1)min(-1) and plant extract 2: 14.0+/-0.5 ml kg(-1)min(-1), diabetic control: 10.9+/-0.6 ml kg(-1)min(-1) versus plant extract 1: 19.3+/-1.4 ml kg(-1)min(-1) and plant extract 2: 20.5+/-1.5 ml kg(-1)min(-1); high-dose-normal control: 50.9+/-2.6 ml kg(-1)min(-1) versus plant extract 1: 49.8+/-2.6 ml kg(-1)min(-1) and plant extract 2: 48.4+/-2.4 ml kg(-1)min(-1), diabetic control: 26.9+/-1.6 ml kg(-1)min(-1) versus plant extract 1: 33.5+/-1.7 ml kg(-1)min(-1) and plant extract 2: 37.2+/-1.9 ml kg(-1)min(-1); P<0.05, respectively). These results suggest that a single administration of the two Mongolian plant extracts can improve glucose utilization and insulin resistance in diabetic rats.
Mesh Headings (Keywords): Animals, Blood Glucose, Carotid Artery, Common, Diabetes Mellitus, Experimental, Glucose Clamp Technique, Glucose Tolerance Test, Hypoglycemic Agents, Insulin, Male, Mongolia, Plant Extracts, Rats, Rats, Wistar
Check for Full Text / PubMed Unique Identifier (PMID): 16930759
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.