Leukoaraiosis is a Risk Factor for Symptomatic Intracerebral Hemorrhage After Thrombolysis for Acute Stroke.
From: Klinik für Neurologie, ZNN, Klinikum der Goethe-Universität, Schleusenweg 2-16, 60528 Frankfurt, Germany. tnh@rz.uni-frankfurt.de
Stroke; a journal of cerebral circulation
- Publish Date: Oct 2006
- ISSN: 1524-4628
- Volume: 37
- Issue: 10
- Pages: 2463-6
- Medium: Internet
- Language: English
- Citation (JAMA): Neumann-Haefelin Tobias, Hoelig Silke, Berkefeld Joachim, et al. Leukoaraiosis is a Risk Factor for Symptomatic Intracerebral Hemorrhage After Thrombolysis for Acute Stroke.. Stroke Oct 2006;37:2463-6
Abstract
BACKGROUND AND PURPOSE: The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis for acute stroke. METHODS: In this retrospective, multicenter analysis, we evaluated data from acute anterior circulation stroke patients (n=449; <6 hours after symptom onset) treated with thrombolysis. All patients had received standard magnetic resonance imaging evaluation before thrombolysis, including a high-quality T2-weighted sequence. For the analysis, LA in the deep white matter was dichotomized into absent or mild versus moderate or severe (corresponding to Fazekas scores of 0 to 1 versus 2 to 3). RESULTS: The rate of sICH was significantly more frequent in patients with moderate to severe LA of the deep white matter (n=12 of 114; 10.5%) than in patients without relevant LA (n=13 of 335; 3.8%), corresponding to an odds ratio of 2.9 (95% CI, 1.29 to 6.59; P=0.015). In a logistic-regression analysis (including age, National Institutes of Health Stroke Scale score at presentation, and type of thrombolytic treatment), LA remained a significant independent risk factor (odds ratio, 2.9; P=0.03). CONCLUSIONS: LA of the deep white matter is an independent risk factor for sICH after thrombolytic treatment for acute stroke.
Mesh Headings (Keywords): Aged, Aged, 80 and over, Cerebral Hemorrhage, Disease Susceptibility, Female, Fibrinolytic Agents, Humans, Leukoaraiosis, Male, Middle Aged, Retrospective Studies, Risk Factors, Single-Blind Method, Stroke, Thrombolytic Therapy
Check for Full Text / PubMed Unique Identifier (PMID): 16931786
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