The Vasopressin System: Physiology and Clinical Strategies.
From: Klinik für Anästhesiologie und Intensivmedizin, Germany. tanja.treschan@uni-essen.de
Anesthesiology
- Publish Date: Sep 2006
- ISSN: 0003-3022
- Volume: 105
- Issue: 3
- Pages: 599-612; quiz 639-40
- Medium: Print
- Language: English
- Citation (JAMA): Treschan Tanja A, Peters Jürgen, et al. The Vasopressin System: Physiology and Clinical Strategies.. Anesthesiology Sep 2006;105:599-612; quiz 639-40
Abstract
Vasopressin, synthesized in the hypothalamus, is released by increased plasma osmolality, decreased arterial pressure, and reductions in cardiac volume. Three subtypes of vasopressin receptors, V1, V2, and V3, have been identified, mediating vasoconstriction, water reabsorption, and central nervous system effects, respectively. Vasopressin and its analogs have been studied intensively for the treatment of states of “relative vasopressin deficiency,” such as sepsis, vasodilatory shock, intraoperative hypotension, and cardiopulmonary resuscitation. Infusion of vasopressin (0.01-0.04 U/min) decreases catecholamine requirements in patients with sepsis and other types of vasodilatory shock. Bolus application of 1 mg terlipressin, the V1 agonist, reverses refractory hypotension in anesthetized patients and has been studied in patients with septic shock and chronic liver failure. During cardiopulmonary resuscitation, a 40-U bolus dose of vasopressin may be considered to replace the first or second bolus of epinephrine regardless of the initial rhythm. The side effects of vasopressin and its analogs must be further characterized.
Mesh Headings (Keywords): Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Blood Pressure, Cardiopulmonary Resuscitation, Hemostasis, Humans, Hypertension, Hypertension, Portal, Neuroendocrine Tumors, Receptors, Vasopressin, Shock, Septic, Vasopressins, Water-Electrolyte Balance
Check for Full Text / PubMed Unique Identifier (PMID): 16931995
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