Polymorphisms in the E-cadherin (Cdh1) Gene Promoter and the Risk of Bladder Cancer.
From: Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
European journal of cancer (Oxford, England : 1990)
- Publish Date: Dec 2006
- ISSN: 0959-8049
- Volume: 42
- Issue: 18
- Pages: 3219-27
- Medium: Print
- Language: English
- Citation (JAMA): Kiemeney Lambertus A, van Houwelingen Kjeld P, Bogaerts Manon, et al. Polymorphisms in the E-cadherin (Cdh1) Gene Promoter and the Risk of Bladder Cancer.. Eur. J. Cancer Dec 2006;42:3219-27
Abstract
AIM: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. METHODS: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. RESULTS: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. CONCLUSION: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.
Mesh Headings (Keywords): Adult, Aged, Aged, 80 and over, Cadherins, Gene Frequency, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Urinary Bladder Neoplasms
Check for Full Text / PubMed Unique Identifier (PMID): 16934975
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