Expression of Cystatin C in the Rat Endometrium During the Peri-implantation Period.
From: Department of Physiology and Pharmacology, The University of Western Ontario, London, Ont., Canada N6A 5C1.
Biochemical and biophysical research communications
- Publish Date: Oct 2006
- ISSN: 0006-291X
- Volume: 349
- Issue: 1
- Pages: 236-44
- Medium: Print
- Language: English
- Citation (JAMA): Quinn Claire E, Simmons David G, Kennedy Thomas G, et al. Expression of Cystatin C in the Rat Endometrium During the Peri-implantation Period.. Biochem. Biophys. Res. Commun. Oct 2006;349:236-44
Abstract
Endometrial receptivity for embryo implantation in the rat is a transient state occurring on day 5 of pregnancy or pseudopregnancy and is controlled by estrogen and progesterone. To identify genes potentially involved in receptivity, a uterine cDNA library was screened. An interesting pattern for Cystatin C (Cst3) expression was discovered with a peak in abundance just prior to embryo implantation (day 4 of pregnancy) followed by a significant drop the following day when implantation is initiated. Histology localized Cst3 mRNA and CST3 protein to the glandular epithelium on day 4 of pregnancy suggesting that it is secreted into the uterine lumen at this time. In ovariectomized rats endometrial Cst3 mRNA levels decreased within 3h of treatment with estradiol; this effect was inhibited by the anti-estrogen, ICI 182, 780. The data suggest that the endometrial expression of the cysteine protease inhibitor, Cst3, is modulated by estrogen during the peri-implantation period.
Mesh Headings (Keywords): Animals, Cystatins, Embryo Implantation, Endometrium, Endothelial Cells, Estradiol, Estrogen Antagonists, Female, Gene Expression Regulation, Gene Library, Nucleic Acid Hybridization, RNA, Messenger, Rats, Rats, Sprague-Dawley
Check for Full Text / PubMed Unique Identifier (PMID): 16935259
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