The Alpha4beta2 Nicotinic Acetylcholine Receptor Agonist Tc-2559 Impairs Long-term Potentiation in the Dentate Gyrus in Vivo.
From: Lilly Research Centre, Eli Lilly & Co Ltd, Erl Wood Manor, Windlesham, Surrey, UK.
Neuroscience letters
- Publish Date: Oct 2006
- ISSN: 0304-3940
- Volume: 406
- Issue: 3
- Pages: 183-8
- Medium: Print
- Language: English
- Citation (JAMA): Wang Yun, Sherwood John L, Lodge David, et al. The Alpha4beta2 Nicotinic Acetylcholine Receptor Agonist Tc-2559 Impairs Long-term Potentiation in the Dentate Gyrus in Vivo.. Neurosci. Lett. Oct 2006;406:183-8
Abstract
Nicotinic acetylcholine receptors (nAChR) are widely expressed throughout the nervous system, are involved in some fast excitatory neurotransmission, and play an important role in modulating the release of several neurotransmitters, including the major excitatory and inhibitory neurotransmitters, glutamate and GABA. We used a recently characterised alpha4beta2 nAChR subunit selective partial agonist, TC-2559, to study the effect of alpha4beta2 nAChR activation on synaptic plasticity in the medio-dorsal perforant pathway input to the dentate gyrus, in the intact nervous system in vivo. We show for the first time, that the selective activation of alpha4beta2 containing nAChR can reduce the level of long-term potentiation (LTP) induced by high frequency stimulation, an effect that was reversed by the selective antagonist, dihydro-beta-erythroidine (DbetaHE). This modulator role of nAChRs is in contrast to previous findings that used broad spectrum agonists, highlighting the complex actions of nicotine.
Mesh Headings (Keywords): Analysis of Variance, Animals, Dentate Gyrus, Dihydro-beta-Erythroidine, Dose-Response Relationship, Radiation, Electric Stimulation, Long-Term Potentiation, Male, Nicotinic Antagonists, Pyridines, Rats, Rats, Sprague-Dawley, Receptors, Nicotinic, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16935422
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.