Apolipoprotein E Exerts Selective and Differential Control over Vitamin E Concentrations in Different Areas of Mammalian Brain.
From: Research Service and GRECC, VA Medical Center, Minneapolis, Minnesota 55417, USA. vatas001@umn.edu
Journal of neuroscience research
- Publish Date: Nov 2006
- ISSN: 0360-4012
- Volume: 84
- Issue: 6
- Pages: 1335-42
- Medium: Print
- Language: English
- Citation (JAMA): Vatassery Govind T, Lam Cornelius, Smith W Ed, et al. Apolipoprotein E Exerts Selective and Differential Control over Vitamin E Concentrations in Different Areas of Mammalian Brain.. J. Neurosci. Res. Nov 2006;84:1335-42
Abstract
Apolipoprotein E (apoE) is known to be a risk factor for the incidence of Alzheimer’s disease (AD). In addition, vitamin E has been reported to have a role in the treatment of AD. We examined the potential interrelationship between vitamin E and apoE in brain. As the first step, we determined the concentrations of alpha-tocopherol in selected brain regions of apoE-deficient mice at different ages. The mice were fed normal rodent chow. All regions of the brain in apoE-deficient mice contained less alpha-tocopherol than control samples at 2.5 months of age, the initial time of study. This trend continued for 9.5 months for most regions except the spinal cord and cerebellum. Tocopherol levels in these latter regions of apoE-deficient animals increased to control levels during the study. Serum alpha-tocopherol and cholesterol levels were high in the apoE-deficient animals; however, the CNS cholesterol levels were the same in apoE-deficient and control mice. This suggests that 1) the decline in brain alpha-tocopherol in apoE deficiency is not due to overall alterations in lipid metabolism; and 2) the processing of alpha-tocopherol in brain follows a separate pathway than that of cholesterol. Subcellular concentrations of alpha-tocopherol were unaltered by apoE deficiency indicating that intracellular handling of tocopherol is not affected by apoE. ApoE may be an important protein controlling vitamin E levels in specific brain regions. Further understanding of the interactions between apoE and vitamin E could be important in the appropriate use of vitamin E in AD.
Mesh Headings (Keywords): Aging, Animals, Antioxidants, Apolipoproteins E, Brain Chemistry, Cholesterol, Chromatography, High Pressure Liquid, Male, Mice, Mice, Knockout, Subcellular Fractions, Vitamin E
Check for Full Text / PubMed Unique Identifier (PMID): 16941498
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.