Dendrite-selective Redistribution of the Chemokine Receptor Cxcr4 Following Agonist Stimulation.
From: Institut National de la Santé Et de la Recherche Médicale, I.N.S.E.R.M., Unité 643, I.T.E.R.T, CHU Hotel-Dieu, University of Nantes, 30 Bd Jean Monnet, 44035 Nantes Cedex 01, France.
Molecular and cellular neurosciences
- Publish Date: Oct 2006
- ISSN: 1044-7431
- Volume: 33
- Issue: 2
- Pages: 160-9
- Medium: Print
- Language: English
- Citation (JAMA): Baudouin Stéphane J, Pujol Fabien, Nicot Arnaud, et al. Dendrite-selective Redistribution of the Chemokine Receptor Cxcr4 Following Agonist Stimulation.. Mol. Cell. Neurosci. Oct 2006;33:160-9
Abstract
The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.
Mesh Headings (Keywords): Animals, Arrestins, Axons, Cell Compartmentation, Cells, Cultured, Chemokine CXCL12, Chemokines, CXC, Dendrites, Endocytosis, Endosomes, Green Fluorescent Proteins, Hippocampus, Male, Protein Transport, Rats, Rats, Sprague-Dawley, Receptors, CXCR4, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 16952464
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