Trichinella: Differing Effects of Antigens from Encapsulated and Non-encapsulated Species on in Vitro Nitric Oxide Production.
From: Laboratorio de Inmunología Parasitaria y Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro, s/n 37007, Salamanca, Spain.
Veterinary parasitology
- Publish Date: Jan 2007
- ISSN: 0304-4017
- Volume: 143
- Issue: 1
- Pages: 86-90
- Medium: Print
- Language: English
- Citation (JAMA): Andrade M Amparo, Siles-Lucas Mar, López-Abán Julio, et al. Trichinella: Differing Effects of Antigens from Encapsulated and Non-encapsulated Species on in Vitro Nitric Oxide Production.. Vet. Parasitol. Jan 2007;143:86-90
Abstract
Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host-parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L1 antigens from four encapsulated (T. spiralis, T. britovi, T. nelsoni and T. nativa) and one non-encapsulated (T. pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models.
Mesh Headings (Keywords): Animals, Antigens, Helminth, Cells, Cultured, Genotype, Host-Parasite Interactions, Humans, Intestinal Diseases, Parasitic, Macrophages, Alveolar, Nitric Oxide, Rats, Species Specificity, Trichinella, Trichinosis
Check for Full Text / PubMed Unique Identifier (PMID): 16959431
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