The Mechanical Properties and Osteoconductivity of Hydroxyapatite Bone Scaffolds with Multi-scale Porosity.
From: Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign, 1206 W. Green St., Urbana, IL 61801, USA.
Biomaterials
- Publish Date: Jan 2007
- ISSN: 0142-9612
- Volume: 28
- Issue: 1
- Pages: 45-54
- Medium: Print
- Language: English
- Citation (JAMA): Woodard Joseph R, Hilldore Amanda J, Lan Sheeny K, et al. The Mechanical Properties and Osteoconductivity of Hydroxyapatite Bone Scaffolds with Multi-scale Porosity.. Biomaterials Jan 2007;28:45-54
Abstract
The relative osteoconductivity and the change in the mechanical properties of hydroxyapatite (HA) scaffolds with multi-scale porosity were compared to scaffolds with a single pore size. Non-microporous (NMP) scaffolds contained only macroporosity (250-350 microm) and microporous (MP) scaffolds contained both macroporosity and microporosity (2-8 microm). Recombinant human bone morphogenetic protein-2 (rhBMP-2) was incorporated into all scaffolds via gelatin microspheres prior to implantation into the latissimus dorsi muscle of Yorkshire pigs. After 8 weeks, only the MP scaffolds contained bone. The result demonstrates the efficacy of the MP scaffolds as drug carriers. Implanted and as-fabricated scaffolds were compared using histology, microcomputed tomography, scanning electron microscopy, and compression testing. Implanted scaffolds exhibited a stress-strain response similar to that of cancellous bone with strengths between those of cancellous and cortical bone. The strength and stiffness of implanted NMP scaffolds decreased by 15% and 46%, respectively. Implanted MP scaffolds lost 30% of their strength and 31% of their stiffness. Bone arrested crack propagation effectively in MP scaffolds. The change in mechanical behavior is discussed and the study demonstrates the importance of scaffold microporosity on bone ingrowth and on the mechanical behavior of HA implant materials.
Mesh Headings (Keywords): Animals, Bone Regeneration, Durapatite, Humans, Microscopy, Electron, Scanning, Osteoblasts, Porosity, Stress, Mechanical, Swine
Check for Full Text / PubMed Unique Identifier (PMID): 16963118
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.