Emerging Roles of Beta-arrestins.
From: The Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6838, USA.
Cell cycle (Georgetown, Tex.)
- Publish Date: Sep 2006
- ISSN: 1551-4005
- Volume: 5
- Issue: 18
- Pages: 2060-3
- Medium: Internet
- Language: English
- Citation (JAMA): Buchanan F Gregory, DuBois Raymond N, et al. Emerging Roles of Beta-arrestins.. Cell Cycle Sep 2006;5:2060-3
Abstract
Arrestins were originally characterized as structural adaptor proteins which modulate the desensitization and trafficking of seven-membrane-spanning receptors. From these seminal observations a multitude of novel functions for this gene family have arisen. Here we review the recently identified roles for beta-arrestin including its nuclear function and roles in development, cellular migration, and metastasis.
Mesh Headings (Keywords): Animals, Arrestins, Cell Movement, Cell Nucleus, Humans, Neoplasm Metastasis, Protein Kinases, Protein Transport, Receptors, G-Protein-Coupled, Signal Transduction, Wnt Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 16969081
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