Ttf-1, a Homeodomain-containing Transcription Factor, Regulates Feeding Behavior in the Rat Hypothalamus.
From: Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Biochemical and biophysical research communications
- Publish Date: Oct 2006
- ISSN: 0006-291X
- Volume: 349
- Issue: 3
- Pages: 969-75
- Medium: Print
- Language: English
- Citation (JAMA): Kim Jae Geun, Nam-Goong Il Seong, Yun Chang Ho, et al. Ttf-1, a Homeodomain-containing Transcription Factor, Regulates Feeding Behavior in the Rat Hypothalamus.. Biochem. Biophys. Res. Commun. Oct 2006;349:969-75
Abstract
TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal’s food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.
Mesh Headings (Keywords): Animals, Body Weight, Feeding Behavior, Hypothalamus, Injections, Intravenous, Male, Neuropeptide Y, Nuclear Proteins, Oligodeoxyribonucleotides, Antisense, Pro-Opiomelanocortin, RNA, Messenger, Rats, Rats, Sprague-Dawley, Transcription Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16970909
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