Identification and Characterization of a Previously Undetected Region Between the Perichondrium and Periosteum of the Developing Avian Limb.
From: Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Developmental biology
- Publish Date: Nov 2006
- ISSN: 0012-1606
- Volume: 299
- Issue: 2
- Pages: 505-16
- Medium: Print
- Language: English
- Citation (JAMA): Crochiere Marsha L, Kubilus James K, Linsenmayer Thomas F, et al. Identification and Characterization of a Previously Undetected Region Between the Perichondrium and Periosteum of the Developing Avian Limb.. Dev. Biol. Nov 2006;299:505-16
Abstract
In developing long bones, the growing cartilage and bone are surrounded by the fibrous perichondrium (PC) and periosteum (PO), respectively, which provide cells for the appositional growth (i.e., growth in diameter) of these tissues. Also during the longitudinal growth of a bone, the cartilage is continuously replaced by bony tissue, giving rise to the widely held assumption that the PC concomitantly gives rise to the PO. Except for this morphological correlate, however, no evidence exists for a direct conversion of PC cells to PO cells, and our observations presented here question this assumption. Instead, we have obtained evidence suggesting that a previously undescribed region exists between the PC and PO. This region, termed the border region (BR), has several unique characteristics which distinguish it from either the PC or PO, including (1) its lack of being determined to differentiate as either cartilage or bone, (2) its ability to preferentially elicit the invasion of blood vessels, and (3) its ability to undergo preferential growth.
Mesh Headings (Keywords): Animals, Chick Embryo, Chondrocytes, Extremities, Organ Culture Techniques, Periosteum
Check for Full Text / PubMed Unique Identifier (PMID): 16978598
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.