Cytochrome P450 Systems--biological Variations of Electron Transport Chains.
From: FR 8.3-Biochemistry, Saarland University, D-66041 Saarbrücken, Germany.
Biochimica et biophysica acta
- Publish Date: Mar 2007
- ISSN: 0006-3002
- Volume: 1770
- Issue: 3
- Pages: 330-44
- Medium: Print
- Language: English
- Citation (JAMA): Hannemann Frank, Bichet Andreas, Ewen Kerstin M, et al. Cytochrome P450 Systems--biological Variations of Electron Transport Chains.. Biochim. Biophys. Acta Mar 2007;1770:330-44
Abstract
Cytochromes P450 (P450) are hemoproteins encoded by a superfamily of genes nearly ubiquitously distributed in different organisms from all biological kingdoms. The reactions carried out by P450s are extremely diverse and contribute to the biotransformation of drugs, the bioconversion of xenobiotics, the bioactivation of chemical carcinogens, the biosynthesis of physiologically important compounds such as steroids, fatty acids, eicosanoids, fat-soluble vitamins and bile acids, the conversion of alkanes, terpenes and aromatic compounds as well as the degradation of herbicides and insecticides. Cytochromes P450 belong to the group of external monooxygenases and thus receive the necessary electrons for oxygen cleavage and substrate hydroxylation from different redox partners. The classical as well as the recently discovered P450 redox systems are compiled in this paper and classified according to their composition.
Mesh Headings (Keywords): Animals, Biotransformation, Cytochrome P-450 Enzyme System, Electron Transport, Humans, Hydroxylation, Oxidation-Reduction, Oxygen, Pharmaceutical Preparations, Xenobiotics
Check for Full Text / PubMed Unique Identifier (PMID): 16978787
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