Control of Phospholipase A2 Activities for the Treatment of Inflammatory Conditions.
From: Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. yedgar@md.huji.ac.il
Biochimica et biophysica acta
- Publish Date: Nov 2006
- ISSN: 0006-3002
- Volume: 1761
- Issue: 11
- Pages: 1373-82
- Medium: Print
- Language: English
- Citation (JAMA): Yedgar Saul, Cohen Yuval, Shoseyov David, et al. Control of Phospholipase A2 Activities for the Treatment of Inflammatory Conditions.. Biochim. Biophys. Acta Nov 2006;1761:1373-82
Abstract
Phospholipase-A2 (PLA2) enzymes hydrolyze cell membrane phospholipids to produce arachidonic acid (AA) and lyso-phospholipids (LysoPL), playing a key role in the production of inflammatory lipid mediators, mainly eicosanoids. They are therefore considered pro-inflammatory enzymes and their inhibition has long been recognized as a desirable therapeutic target. However, attempts to develop suitable PLA2 inhibitors for the treatment of inflammatory diseases have yet to succeed. This is due to their functional and structural diversity, and their homeostatic and even anti-inflammatory roles in certain circumstances. In the present review we outline the diversity and functions of PLA2 isoforms, and their interplay in the induction and inhibition of inflammatory processes, with emphasis on discussing approaches for therapeutic manipulation of PLA2 activities.
Mesh Headings (Keywords): Animals, Arachidonic Acid, Eicosanoids, Enzyme Inhibitors, Humans, Inflammation, Lysophospholipids, Membrane Lipids, Phospholipases A, Phospholipases A2
Check for Full Text / PubMed Unique Identifier (PMID): 16978919
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