Mutational Screening of Foxo3a and Foxo1a in Women with Premature Ovarian Failure.
From: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Fertility and sterility
- Publish Date: Nov 2006
- ISSN: 1556-5653
- Volume: 86
- Issue: 5
- Pages: 1518-21
- Medium: Internet
- Language: English
- Citation (JAMA): Watkins Wendy J, Umbers Alexandra J, Woad Kathryn J, et al. Mutational Screening of Foxo3a and Foxo1a in Women with Premature Ovarian Failure.. Fertil. Steril. Nov 2006;86:1518-21
Abstract
FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies.
Mesh Headings (Keywords): DNA Mutational Analysis, Female, Forkhead Transcription Factors, Genetic Predisposition to Disease, Genetic Screening, Humans, Mutation, New Zealand, Ovarian Failure, Premature, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Slovenia
Check for Full Text / PubMed Unique Identifier (PMID): 16979636
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