Episodic Vestibular Disruption Following Ablation of the Inferior Olive in Rats: Behavioral Correlates.
From: Department of Anatomy and Cell Biology, Indiana University School of Medicine, Evansville Center for Medical Education, 8600 University Blvd., Evansville, IN 47712, United States. dsaxon@IUPUI.edu
Behavioural brain research
- Publish Date: Nov 2006
- ISSN: 0166-4328
- Volume: 175
- Issue: 1
- Pages: 128-38
- Medium: Print
- Language: English
- Citation (JAMA): Saxon Dale W, White Gary, et al. Episodic Vestibular Disruption Following Ablation of the Inferior Olive in Rats: Behavioral Correlates.. Behav. Brain Res. Nov 2006;175:128-38
Abstract
The experiments herein investigate whether the behavioral responses to transient and episodic vestibular disruption and permanent ablation are distinct in the absence of climbing fiber input. Subjects in group 1 received an IP injection of PBS followed by an IP injection of niacinamide. Seven days later these rats received the first of 3 serial transtympanic injections of TTX on the same side with 7 days between each injection. Following each TTX injection rats displayed unilateral vestibular symptoms that persisted beyond 48h. Spontaneous barrel rolling behavior was not observed. Group 2 subjects received an IP injection of 3-acetylpyridine (3-AP)+niacinamide followed by the same TTX regimen as group 1. Following each TTX injection vestibular symptoms (severe body twisting and persistent spontaneous barrel rolling) emerged rapidly (<15min) and resolved by 72h. Group 3 subjects received an IP injection of 3-AP+niacinamide and 7 days later a single unilateral transtympanic injection of sodium arsanilate. Rats in group 3 developed vestibular symptoms similar to those observed in group 2 although there was no resolution of these symptoms. The results indicate that TTX has a rapid rate of infiltration and blockade of the VIIIth nerve that persists for >48h and then completely resolves. The contrast in vestibular symptoms between groups 1 and 2 suggest that climbing fibers are recruited soon after onset of vestibular disruption and play a role in attenuating the severity of vestibular symptoms associated with transient/episodic vestibular disruption.
Mesh Headings (Keywords): Animals, Autonomic Nerve Block, Behavior, Animal, Drug Administration Routes, Drug Administration Schedule, Drug Interactions, Male, Neurotoxins, Niacinamide, Olivary Nucleus, Poisons, Pyridines, Rats, Rats, Sprague-Dawley, Reflex, Vestibulo-Ocular, Silver Staining, Tetrodotoxin, Vestibular Diseases, Vestibulocochlear Nerve
Check for Full Text / PubMed Unique Identifier (PMID): 16979764
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