Cutting Edge: Paracrine, but Not Autocrine, Il-2 Signaling is Sustained During Early Antiviral Cd4 T Cell Response.
From: Center for Immunotherapy of Cancer and Infectious Diseases and Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Oct 2006
- ISSN: 0022-1767
- Volume: 177
- Issue: 7
- Pages: 4257-61
- Medium: Print
- Language: English
- Citation (JAMA): Long Meixiao, Adler Adam J, et al. Cutting Edge: Paracrine, but Not Autocrine, Il-2 Signaling is Sustained During Early Antiviral Cd4 T Cell Response.. J. Immunol. Oct 2006;177:4257-61
Abstract
IL-2 is expressed predominantly by activated T cells, and regulates T cell function by activating, via its receptor, the latent transcription factor STAT5. This signaling can occur in either a paracrine (between cells) or an autocrine (same cell) manner, although the kinetics by which these two signaling modes operate during in vivo T cell responses are unknown. In the current study, IL-2 expression and signaling in a clonotypic population of antiviral CD4+ T cells was analyzed by flow cytometry during the initial 24 h of priming. IL-2 expression and STAT5 activation peaked in parallel, but surprisingly, were almost completely mutually exclusive. Thus, only paracrine IL-2 signaling could be observed. As an additional indication of the efficiency of paracrine IL-2 signaling, polyclonal CD4+CD25+Foxp3+ regulatory T cells displayed detectable STAT5 activation under steady-state conditions, which was strongly enhanced by neighboring IL-2-expressing antiviral CD4 cells.
Mesh Headings (Keywords): Adoptive Transfer, Animals, Autocrine Communication, CD4-Positive T-Lymphocytes, Flow Cytometry, Interleukin-2, Lymphocyte Activation, Mice, Paracrine Communication, STAT5 Transcription Factor, Signal Transduction, Vaccinia virus
Check for Full Text / PubMed Unique Identifier (PMID): 16982857
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