Intricacies and Surprises of Nuclear-mitochondrial Co-evolution.
The Biochemical journal
- Publish Date: Oct 2006
- ISSN: 1470-8728
- Volume: 399
- Issue: 2
- Pages: e7-9
- Medium: Internet
- Language: English
- Citation (JAMA): Willkomm Dagmar K, Hartmann Roland K, et al. Intricacies and Surprises of Nuclear-mitochondrial Co-evolution.. Biochem. J. Oct 2006;399:e7-9
Abstract
In this issue of the Biochemical Journal, Watanabe and colleagues disclose another fascinating facet of the mitochondrial protein synthesis machinery: one of the two nematode mitochondrial elongation factors Tu, EF-Tu1, specifically recognizes the D-arm of T-armless tRNAs via a 57-amino-acid C-terminal extension that compensates for the reduction in tRNA structure. This principle provides a paradigm for the evolutionary events thought to have ignited the transition from an ancient ‘RNA world’ to the ‘protein world’ of today.
Mesh Headings (Keywords): Animals, Cell Nucleus, Evolution, Mitochondria, Peptide Elongation Factor Tu, Protein Biosynthesis
Check for Full Text / PubMed Unique Identifier (PMID): 16987107
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