Checkpoints and Restriction Points in Bacteria and Eukaryotic Cells.
From: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA. cooper@umich.edu
BioEssays : news and reviews in molecular, cellular and developmental biology
- Publish Date: Oct 2006
- ISSN: 0265-9247
- Volume: 28
- Issue: 10
- Pages: 1035-9
- Medium: Print
- Language: English
- Citation (JAMA): Cooper Stephen, et al. Checkpoints and Restriction Points in Bacteria and Eukaryotic Cells.. Bioessays Oct 2006;28:1035-9
Abstract
Bacterial checkpoints, analogous to those proposed to exist in eukaryotic cells, offer insights into the definition of a checkpoint. Examination of bacterial “checkpoint” or arrest phenomena illustrate problems with a too-casual application of the checkpoint idea to eukaryotic phenomena. The question raised here is whether there are cellular processes that “check” whether a cellular process is completed. It is possible that many eukaryotic “checkpoints” may not have “checking” functions. Some of the ubiquitous checkpoint phenomena widely described may be merely the result of the inherent incompleteness of earlier events preventing the initiation of subsequent events.
Mesh Headings (Keywords): Animals, Bacteria, Cell Cycle, DNA Replication, Eukaryotic Cells, Models, Biological
Check for Full Text / PubMed Unique Identifier (PMID): 16998839
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