Antiinflammatory but No Neuroprotective Effects of Melatonin Under Clinical Treatment Conditions in Rabbit Models of Bacterial Meningitis.
From: Department of Neurology, University Hospital, Georg-August-University of Göttingen, Göttingen, Germany.
Journal of neuroscience research
- Publish Date: Nov 2006
- ISSN: 0360-4012
- Volume: 84
- Issue: 7
- Pages: 1575-9
- Medium: Print
- Language: English
- Citation (JAMA): Spreer Annette, Gerber Joachim, Baake Daniel, et al. Antiinflammatory but No Neuroprotective Effects of Melatonin Under Clinical Treatment Conditions in Rabbit Models of Bacterial Meningitis.. J. Neurosci. Res. Nov 2006;84:1575-9
Abstract
Neuronal injury is frequent in bacterial meningitis, resulting in a high rate of death and neurological sequelae. In a search of potential neuroprotective strategies for treatment of bacterial meningitis, the antioxidant melatonin was neuroprotective in cell culture experiments and in a rabbit Streptococcus pneumoniae meningitis model, when treatment was started at the time of infection. In the present study, adjunctive melatonin treatment applied from the beginning of antibiotic therapy 12 hr after infection at a dose of 1.67 mg/kg/hr resulted in plasma concentrations of 451 +/- 198 ng/ml, cerebrospinal fluid (CSF) concentrations of 154 +/- 57 ng/ml and a CSF-to-plasma ratio of 0.38 +/- 0.19 (mean +/- SD). Melatonin therapy had antiinflammatory effects but did not reduce neuronal injury in either a rabbit model of gram-positive Streptococcus pneumoniae or gram-negative Escherichia coli meningitis.
Mesh Headings (Keywords): Animals, Anti-Inflammatory Agents, Antioxidants, Apoptosis, Cell Count, Dinoprostone, Disease Models, Animal, Hippocampus, Melatonin, Meningitis, Bacterial, Neurons, Rabbits, Statistics, Nonparametric, Streptococcus pneumoniae, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16998917
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