Par3 Acts As a Molecular Organizer to Define the Apical Domain of Chick Neuroepithelial Cells.
From: Instituto Gulbenkian de Ciência, Ap. 14, Oeiras, Portugal.
Journal of cell science
- Publish Date: Oct 2006
- ISSN: 0021-9533
- Volume: 119
- Issue: Pt 20
- Pages: 4293-304
- Medium: Print
- Language: English
- Citation (JAMA): Afonso Cristina, Henrique Domingos, et al. Par3 Acts As a Molecular Organizer to Define the Apical Domain of Chick Neuroepithelial Cells.. J. Cell. Sci. Oct 2006;119:4293-304
Abstract
Neural progenitors in the vertebrate nervous system are fully polarized epithelial cells, with intercellular junctions at the apical region. These progenitor cells remain within the neuroepithelium throughout neurogenesis, and will ultimately give rise to all the neurons in the mature nervous system. We have addressed the role of the PAR polarity complex in vertebrate neuroepithelial polarity and show that PAR3 functions as the initial scaffold to assemble and organize the PAR complex at the apical region of neuroepithelial cells, coordinating also the recruitment of additional polarity complexes and junction-associated proteins to the same region, while restricting other polarity proteins to the basolateral membrane. We propose that PAR3 acts as a molecular organizer to connect the acquisition of apico-basal polarity with the positioning and formation of junctional structures in neuroepithelial cells, a function of upmost importance for the morphogenesis of embryonic neural tissue and the process of neurogenesis.
Mesh Headings (Keywords): Animals, Cell Adhesion, Cell Polarity, Chick Embryo, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Immunoprecipitation, In Situ Hybridization, Microscopy, Confocal, Microscopy, Fluorescence, Neuroepithelial Cells, Receptors, Thrombin, Recombinant Fusion Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17003110
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.