Glycaemic Control Throughout Pregnancy and Risk of Pre-eclampsia in Women with Type I Diabetes.
From: Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK. rosemary.temple@nnuh.nhs.uk
BJOG : an international journal of obstetrics and gynaecology
- Publish Date: Nov 2006
- ISSN: 1470-0328
- Volume: 113
- Issue: 11
- Pages: 1329-32
- Medium: Print
- Language: English
- Citation (JAMA): Temple R C, Aldridge V, Stanley K, et al. Glycaemic Control Throughout Pregnancy and Risk of Pre-eclampsia in Women with Type I Diabetes.. Nov 2006;113:1329-32
Abstract
The aim of this study was to examine the influence of pre-pregnancy care and its effect on early glycaemic control and also the effect of glycaemic control in later pregnancy on risk of pre-eclampsia in women with type I diabetes. A prospective cohort study of 290 consecutive nonselected pregnancies in women with type I diabetes was performed from 1991 to 2002. We examined the relationship of monthly glycosylated haemoglobin (HbA1c) level, pre-pregnancy care, parity, diabetes duration, microvascular complications, maternal age, weight and smoking with risk of pre-eclampsia. Pre-eclampsia developed in 31/243 singleton births (12.8%). HbA1c level at 24 weeks was significantly increased in women with pre-eclampsia compared with women without pre-eclampsia (6.0 versus 5.6%, P= 0.017) and was, after nulliparity, the strongest independent predictor of increased risk (OR 1.65 for each 1% increase in HbA1c; P= 0.01). In contrast, there was no relationship between pre-pregnancy care or HbA1c level at booking and risk of pre-eclampsia.
Mesh Headings (Keywords): Adult, Analysis of Variance, Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 1, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Pre-Eclampsia, Preconception Care, Pregnancy, Pregnancy in Diabetics, Prospective Studies, Risk Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17004981
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