Deiodinases: Implications of the Local Control of Thyroid Hormone Action.
From: Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. abianco@partners.org
The Journal of clinical investigation
- Publish Date: Oct 2006
- ISSN: 0021-9738
- Volume: 116
- Issue: 10
- Pages: 2571-9
- Medium: Print
- Language: English
- Citation (JAMA): Bianco Antonio C, Kim Brian W, et al. Deiodinases: Implications of the Local Control of Thyroid Hormone Action.. J. Clin. Invest. Oct 2006;116:2571-9
Abstract
The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
Mesh Headings (Keywords): Animals, Energy Metabolism, Homeostasis, Humans, Iodide Peroxidase, Models, Biological, Models, Molecular, Protein Conformation, Signal Transduction, Thyroid Hormones
Check for Full Text / PubMed Unique Identifier (PMID): 17016550
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