Unwinding a Path to Nuclear Beta-catenin.
From: Program of Neurobiology, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA. xi.he@childrens.harvard.edu
Cell
- Publish Date: Oct 2006
- ISSN: 0092-8674
- Volume: 127
- Issue: 1
- Pages: 40-2
- Medium: Print
- Language: English
- Citation (JAMA): He Xi, et al. Unwinding a Path to Nuclear Beta-catenin.. Cell Oct 2006;127:40-2
Abstract
In this issue of Cell, Yang et al. (2006b) show that PDGF, a growth factor that induces the transition of epithelial cells to mesenchymal cells, stimulates the c-Abl kinase-dependent phosphorylation of p68 RNA helicase. Phosphorylated p68 dissociates beta-catenin from the Axin destruction complex, thereby promoting nuclear beta-catenin signaling independent of Wnt activation.
Mesh Headings (Keywords): Animals, Cell Differentiation, Cell Nucleus, DEAD-box RNA Helicases, Humans, Platelet-Derived Growth Factor, Proto-Oncogene Proteins c-abl, Repressor Proteins, Signal Transduction, Wnt Proteins, beta Catenin
Check for Full Text / PubMed Unique Identifier (PMID): 17018273
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