Antiaggressive Effects of Mpep, a Selective Antagonist of Mglu5 Receptors, in Agonistic Interactions Between Male Mice.
From: Department of Psychobiology, Faculty of Psychology, Campus de Teatinos s/n, University of Málaga, 29071 Málaga, Spain. navahuma@uma.es
European journal of pharmacology
- Publish Date: Dec 2006
- ISSN: 0014-2999
- Volume: 551
- Issue: 1-3
- Pages: 67-70
- Medium: Print
- Language: English
- Citation (JAMA): Navarro José Francisco, Postigo Diana, Martín Mercedes, et al. Antiaggressive Effects of Mpep, a Selective Antagonist of Mglu5 Receptors, in Agonistic Interactions Between Male Mice.. Eur. J. Pharmacol. Dec 2006;551:67-70
Abstract
mGlu5 receptors are highly concentrated in limbic brain structures involved in motivational and emotional behaviours. This study describes the effects of 2-methyl-6-(phenylethylnyl)pyridine (MPEP; 5, 10, 15, 20 and 25 mg/kg, ip), a selective antagonist of the mGlu5 receptors, on agonistic behaviour elicited by isolation in male mice. Individually housed mice were exposed to anosmic opponents in a neutral area 30 min after drug administration. Besides other behaviours, the aggressive (threat and attack) and exploratory behaviours were evaluated during 10 min using an ethologically based analysis. MPEP produced a behavioural profile characterized by a notable decrement of offensive behaviours, accompanied by a significant increase of exploratory behaviours (nonsocial exploration and social investigation). These findings suggest a role for mGlu5 receptors in aggression modulation.
Mesh Headings (Keywords): Aggression, Agonistic Behavior, Animals, Behavior, Animal, Brain, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Exploratory Behavior, Male, Mice, Pyridines, Receptors, Metabotropic Glutamate
Check for Full Text / PubMed Unique Identifier (PMID): 17026995
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