Nicotine Administration Enhances Conditioned Inhibition in Rats.
From: Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA.
European journal of pharmacology
- Publish Date: Dec 2006
- ISSN: 0014-2999
- Volume: 551
- Issue: 1-3
- Pages: 76-9
- Medium: Print
- Language: English
- Citation (JAMA): MacLeod Jill E, Potter Alexandra S, Simoni Michael K, et al. Nicotine Administration Enhances Conditioned Inhibition in Rats.. Eur. J. Pharmacol. Dec 2006;551:76-9
Abstract
The effect of nicotine on conditioned inhibition was examined using a serial feature negative discrimination task. Nicotine (0.35 mg/kg) or vehicle was administered before each of the 16 training sessions. On some trials in each session, a tone was presented and followed by food reward. On other trials, the tone was preceded by a visual stimulus and not reinforced. Nicotine-treated rats exhibited greater discrimination between the two trial types as evidenced by less frequent responding during non-reinforced trials, and learned the discrimination in fewer sessions than vehicle-treated rats. In contrast, there were no group differences in responding during the reinforced trials.
Mesh Headings (Keywords): Analysis of Variance, Animals, Behavior, Animal, Conditioning, Operant, Discrimination Learning, Exploratory Behavior, Inhibition (Psychology), Male, Nicotine, Nicotinic Agonists, Rats, Rats, Long-Evans
Check for Full Text / PubMed Unique Identifier (PMID): 17027751
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