Mrsp1, Encoding a Novel Trichoderma Secreted Protein, is Negatively Regulated by Mapk.
From: Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai 400085, India. prasunmukherjee1@gmail.com
Biochemical and biophysical research communications
- Publish Date: Nov 2006
- ISSN: 0006-291X
- Volume: 350
- Issue: 3
- Pages: 716-22
- Medium: Print
- Language: English
- Citation (JAMA): Mukherjee Prasun K, Hadar Ruthi, Pardovitz-Kedmi Ella, et al. Mrsp1, Encoding a Novel Trichoderma Secreted Protein, is Negatively Regulated by Mapk.. Biochem. Biophys. Res. Commun. Nov 2006;350:716-22
Abstract
A novel gene, MRSP1 (MAP kinase repressed secreted protein 1) is strongly overexpressed in the tmkA MAPK mutant of the biocontrol fungus Trichoderma virens. Transcriptional regulation of MRSP1 is determined by presence or absence of TmkA, rather than by light or sporulation, making it a molecular marker for the unusual, negative, regulation by TmkA. The predicted protein is 15.9 kDa, has a secretory signal, and the four-cysteine pattern, C-X29-CP(G)C-X31-C, may define a new cysteine-rich motif. This is a novel protein with functions not known from any other organism. Conservation in ascomycete, basidiomycete, and Dictyostelium homologs, as well as tight MAPK regulation, might indicate important cellular functions.
Mesh Headings (Keywords): Cells, Cultured, Down-Regulation, Fungal Proteins, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases, Trichoderma
Check for Full Text / PubMed Unique Identifier (PMID): 17027919
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