Neuron-astrocyte Interactions in the Regulation of Brain Energy Metabolism: a Focus on Nmr Spectroscopy.
From: CEA CNRS URA 2210, Service Hospitalier Frederic Joliot, Orsay, France.
Journal of neurochemistry
- Publish Date: Oct 2006
- ISSN: 0022-3042
- Volume: 99
- Issue: 2
- Pages: 393-401
- Medium: Print
- Language: English
- Citation (JAMA): Escartin Carole, Valette Julien, Lebon Vincent, et al. Neuron-astrocyte Interactions in the Regulation of Brain Energy Metabolism: a Focus on Nmr Spectroscopy.. J. Neurochem. Oct 2006;99:393-401
Abstract
An adequate and timely production of ATP by brain cells is of cardinal importance to support the major energetic cost of the rapid processing of information via synaptic and action potentials. Recently, evidence has been accumulated to support the view that the regulation of brain energy metabolism is under the control of an intimate dialogue between astrocytes and neurons. In vitro studies on cultured astrocytes and in vivo studies on rodents have provided evidence that glutamate and Na(+) uptake in astrocytes is a key triggering signal regulating glucose use in the brain. With the advent of NMR spectroscopy, it has been possible to provide experimental evidence to show that energy consumption is mainly devoted to glutamatergic neurotransmission and that glutamate-glutamine cycling is coupled in a approximately 1 : 1 molar stoichiometry to glucose oxidation, at least in the cerebral cortex. This improved understanding of neuron-astrocyte metabolic interactions offers the potential for developing novel therapeutic strategies for many neurological disorders that include a metabolic deficit.
Mesh Headings (Keywords): Animals, Astrocytes, Brain, Cell Communication, Energy Metabolism, Glucose, Humans, Magnetic Resonance Spectroscopy, Neurodegenerative Diseases, Neurons
Check for Full Text / PubMed Unique Identifier (PMID): 17029594
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.