Surfactant Protein D Increases Fusion of Mycobacterium Tuberculosis-containing Phagosomes with Lysosomes in Human Macrophages.
From: Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N-1147 Doan Hall, 410 W. 10th Avenue, Columbus, OH 43210, USA.
Infection and immunity
- Publish Date: Dec 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 12
- Pages: 7005-9
- Medium: Print
- Language: English
- Citation (JAMA): Ferguson J Scott, Martin Jennifer L, Azad Abul K, et al. Surfactant Protein D Increases Fusion of Mycobacterium Tuberculosis-containing Phagosomes with Lysosomes in Human Macrophages.. Infect. Immun. Dec 2006;74:7005-9
Abstract
Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.
Mesh Headings (Keywords): Animals, Humans, Lysosomes, Macrophages, Membrane Fusion, Mycobacterium tuberculosis, Phagocytosis, Phagosomes, Pulmonary Surfactant-Associated Protein D, Rats, Recombinant Proteins, Respiratory Burst
Check for Full Text / PubMed Unique Identifier (PMID): 17030585
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