Formation and Stability of G-quadruplexes Self-assembled from Guanine-rich Strands.
From: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Chemistry (Weinheim an der Bergstrasse, Germany)
- Publish Date: 2007
- ISSN: 0947-6539
- Volume: 13
- Issue: 3
- Pages: 945-9
- Medium: Print
- Language: English
- Citation (JAMA): Zhou Jiang, Yuan Gu, Liu Junjun, et al. Formation and Stability of G-quadruplexes Self-assembled from Guanine-rich Strands.. 2007;13:945-9
Abstract
Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the formation and stability of G-quadruplexes. For the 15 6-nt oligonucleotides tested, ESI-MS indicated that formation of a parallel tetramer quadruplex requires at least four continuous guanines in the 6-nt sequence. In addition, the G-rich strands prefer to employ “self-association” in the formation of the G-quadruplex rather than hybridized integration, and the thermodynamic-stability order of these three G-quadruplexes is Q(2)>Q(1)>Q(3).
Mesh Headings (Keywords): Binding Sites, Binding, Competitive, Crystallography, X-Ray, Guanine, Ligands, Models, Molecular, Molecular Structure, Nylons, Oligodeoxyribonucleotides, Perylene, Piperidones, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization, Thermodynamics
Check for Full Text / PubMed Unique Identifier (PMID): 17036297
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