A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets of Subtype B and C Hiv-1 Primary Viruses.
From: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA. hilao@acpub.duke.edu
Virology
- Publish Date: Sep 2006
- ISSN: 0042-6822
- Volume: 353
- Issue: 2
- Pages: 268-82
- Medium: Print
- Language: English
- Citation (JAMA): Liao Hua-Xin, Sutherland Laura L, Xia Shi-Mao, et al. A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets of Subtype B and C Hiv-1 Primary Viruses.. Virology Sep 2006;353:268-82
Abstract
HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wild-type (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes.
Mesh Headings (Keywords): AIDS Vaccines, Amino Acid Sequence, Animals, Animals, Outbred Strains, Consensus Sequence, Cross Reactions, Gene Products, env, Guinea Pigs, HIV Antibodies, HIV Infections, HIV-1, Immunophenotyping, Molecular Sequence Data, Neutralization Tests, env Gene Products, Human Immunodeficiency Virus
Check for Full Text / PubMed Unique Identifier (PMID): 17039602
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