Galectin-1 is Essential in Tumor Angiogenesis and is a Target for Antiangiogenesis Therapy.
From: Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Pathology, University Maastricht, 6202A2 Maastricht, The Netherlands.
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Oct 2006
- ISSN: 0027-8424
- Volume: 103
- Issue: 43
- Pages: 15975-80
- Medium: Print
- Language: English
- Citation (JAMA): Thijssen Victor L J L, Postel Ruben, Brandwijk Ricardo J M G E, et al. Galectin-1 is Essential in Tumor Angiogenesis and is a Target for Antiangiogenesis Therapy.. Proc. Natl. Acad. Sci. U.S.A. Oct 2006;103:15975-80
Abstract
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
Mesh Headings (Keywords): Animals, Cell Movement, Cell Proliferation, Cells, Cultured, Disease Progression, Endothelial Cells, Galectin 1, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Knockout, Neoplasm Transplantation, Neoplasms, Protein Binding, Proteins, Zebrafish
Check for Full Text / PubMed Unique Identifier (PMID): 17043243
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