Dorsal Hippocampal Dopamine Receptors Are Involved in Mediating Ethanol State-dependent Memory.
From: School of Biology, University College of Science, University of Tehran, Tehran, Iran.
Life sciences
- Publish Date: Jan 2007
- ISSN: 0024-3205
- Volume: 80
- Issue: 4
- Pages: 285-92
- Medium: Print
- Language: English
- Citation (JAMA): Rezayof Ameneh, Motevasseli Tahmineh, Rassouli Yassaman, et al. Dorsal Hippocampal Dopamine Receptors Are Involved in Mediating Ethanol State-dependent Memory.. Life Sci. Jan 2007;80:285-92
Abstract
In the present study, the effects of bilateral injections of dopaminergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol (EtOH) state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of EtOH (0.25, 0.5 and 1 g/kg) dose dependently induced impairment of memory retention. Pre-test administration of EtOH (0.5 g/kg)-induced state-dependent retrieval of the memory acquired under pre-training EtOH (0.5 g/kg) influence. Intra-CA1 administration of the dopamine D(1) receptor agonist, SKF 38393 (0.5, 1 and 2 g/mouse) or the dopamine D(2) receptor agonist, quinpirole (0.25, 0.5 and 1 microg/mouse) alone cannot affect memory retention. While, pre-test intra-CA1 injection of SKF 38393 (2 microg/mouse, intra-CA1) or quinpirole (0.25, 0.5 and 1 microg/mouse, intra-CA1) improved pre-training EtOH (0.5 g/kg)-induced retrieval impairment. Moreover, pre-test administration of SKF 38393 (0.5, 1 and 2 microg/mouse, intra-CA1) or quinpirole (0.5 and 1 microg/mouse, intra-CA1) with an ineffective dose of EtOH (0.25 g/kg) significantly restored the retrieval and induced EtOH state-dependent memory. Furthermore, pre-training injection of the dopamine D(1) receptor antagonist, SCH 23390 (4 microg/mouse), but not the dopamine D(2) receptor antagonist, sulpiride, into the CA1 regions suppressed the learning of a single-trial passive avoidance task. Pre-test intra-CA1 injection of SCH 23390 (2 and 4 microg/mouse, intra-CA1) or sulpiride (2.5 and 5 microg/mouse, intra-CA1) 5 min before the administration of EtOH (0.5 g/kg, i.p.) dose dependently inhibited EtOH state-dependent memory. These findings implicate the involvement of a dorsal hippocampal dopaminergic mechanism in EtOH state-dependent memory and also it can be concluded that there may be a cross-state dependency between EtOH and dopamine.
Mesh Headings (Keywords): 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Animals, Avoidance Learning, Central Nervous System Depressants, Dose-Response Relationship, Drug, Drug Synergism, Ethanol, Hippocampus, Injections, Intraperitoneal, Injections, Intraventricular, Male, Memory, Mice, Mice, Inbred Strains, Quinpirole, Receptors, Dopamine D1, Receptors, Dopamine D2, Sulpiride, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17046026
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