Characterizing Pathogenic Processes in Batten Disease: Use of Small Eukaryotic Model Systems.
From: Center for Aging and Developmental Biology, Aab Institute of Biomedical Science, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Biochimica et biophysica acta
- Publish Date: Oct 2006
- ISSN: 0006-3002
- Volume: 1762
- Issue: 10
- Pages: 906-19
- Medium: Print
- Language: English
- Citation (JAMA): Phillips Seasson N, Muzaffar Neda, Codlin Sandra, et al. Characterizing Pathogenic Processes in Batten Disease: Use of Small Eukaryotic Model Systems.. Biochim. Biophys. Acta Oct 2006;1762:906-19
Abstract
The neuronal ceroid lipofuscinoses (NCLs) are neurodegenerative disorders. Nevertheless, small model organisms, including those lacking a nervous system, have proven invaluable in the study of mechanisms that underlie the disease and in studying the functions of the conserved proteins associated to each disease. From the single-celled yeast, Saccharomyces cerevisiae and Schizosaccharomyces pombe, to the worm, Caenorhabditis elegans and the fruitfly, Drosophila melanogaster, biochemical and, in particular, genetic studies on these organisms have provided insight into the NCLs.
Mesh Headings (Keywords): Amino Acid Sequence, Animals, Caenorhabditis elegans, Disease Models, Animal, Drosophila melanogaster, Genetic Predisposition to Disease, Molecular Sequence Data, Neuronal Ceroid-Lipofuscinoses, Saccharomyces cerevisiae, Schizosaccharomyces, Sequence Homology, Amino Acid
Check for Full Text / PubMed Unique Identifier (PMID): 17049819
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