Role of the Community Effect of Cardiomyocyte in the Entrainment and Reestablishment of Stable Beating Rhythms.
From: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. yasuda.bmi@tmd.ac.jp
Biochemical and biophysical research communications
- Publish Date: Dec 2006
- ISSN: 0006-291X
- Volume: 351
- Issue: 1
- Pages: 209-15
- Medium: Print
- Language: English
- Citation (JAMA): Kojima Kensuke, Kaneko Tomoyuki, Yasuda Kenji, et al. Role of the Community Effect of Cardiomyocyte in the Entrainment and Reestablishment of Stable Beating Rhythms.. Biochem. Biophys. Res. Commun. Dec 2006;351:209-15
Abstract
To investigate the roles that the community effect and entrainment function of cultured cardiomyocyte play in decreasing beating fluctuation and reestablishing synchronized beating, we developed a single-cell-based two-dimensional network culture assay to measure and compare the dynamics of beating rhythm synchronization of individual cells before and after they form networks. Studying the formation of two-cell networks, we found that their synchronized beating tended to be determined by the cardiomyocyte whose beat rate fluctuated less than that of the other cardiomyocyte. We further found that the strength of this tendency increased with the number of cells in the network. These results indicate that (1) beating fluctuation is one of the important factors influencing the reestablishment of a stable synchronous beating rhythm, (2) the larger networks reduce fluctuation, and (3) the formation of a spatial network can itself stabilize cardiomyocyte beat rates.
Mesh Headings (Keywords): Action Potentials, Adaptation, Physiological, Animals, Biological Clocks, Cell Communication, Cells, Cultured, Heart Conduction System, Heart Rate, Mice, Myocytes, Cardiac, Periodicity
Check for Full Text / PubMed Unique Identifier (PMID): 17055457
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.