Polymorphisms in Immune Function Genes and Risk of Non-hodgkin Lymphoma: Findings from the New South Wales Non-hodgkin Lymphoma Study.
From: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892-7240, USA. purduem@mail.nih.gov
Carcinogenesis
- Publish Date: Mar 2007
- ISSN: 0143-3334
- Volume: 28
- Issue: 3
- Pages: 704-12
- Medium: Print
- Language: English
- Citation (JAMA): Purdue Mark P, Lan Qing, Kricker Anne, et al. Polymorphisms in Immune Function Genes and Risk of Non-hodgkin Lymphoma: Findings from the New South Wales Non-hodgkin Lymphoma Study.. Carcinogenesis Mar 2007;28:704-12
Abstract
Recent findings suggest that genetic polymorphisms in TNF and IL10 are associated with an increased risk of non-Hodgkin lymphoma (NHL), particularly for diffuse large B-cell lymphoma (DLBCL). To further investigate the contribution of common genetic variation in key cytokine and innate immunity genes to the etiology of NHL, we genotyped participants in a case-control study of NHL conducted in Australia (545 cases, 498 controls). We investigated 36 single nucleotide polymorphisms in IL10, TNF and 21 other immune function genes. We observed an elevated risk of DLBCL with the IL10 -3575T>A polymorphism [TA genotype: odds ratio (OR)=1.32, 95% confidence interval (CI)=0.86-2.02; AA, OR=1.84, 95% CI=1.10-3.08; trend test, P=0.02]. Our most noteworthy TNF finding was an association between -857C>T and a decreased risk of NHL (CT or TT, OR=0.59, 95% CI=0.42-0.84, P=0.003) and particularly follicular lymphoma (OR=0.40, 95% CI=0.23-0.68, P=0.0009). Additionally, TNF -863C>A was associated with an elevated risk of DLBCL (CA, OR=1.45, 95% CI=0.95-2.21; AA, OR=2.06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships.
Mesh Headings (Keywords): Adult, Aged, Amino Acid Substitution, Chromosome Mapping, Female, Humans, Interleukins, Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Lymphotoxin-alpha, Male, Middle Aged, New South Wales, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Receptors, Leptin, Registries, Risk Factors, Tumor Necrosis Factor-alpha
Check for Full Text / PubMed Unique Identifier (PMID): 17056605
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.