Recombinant Canarypox Virus Vaccine Co-expressing Genes Encoding the Vp2 and Vp5 Outer Capsid Proteins of Bluetongue Virus Induces High Level Protection in Sheep.
From: Equine Viral Disease Laboratory, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Vaccine
- Publish Date: Jan 2007
- ISSN: 0264-410X
- Volume: 25
- Issue: 4
- Pages: 672-8
- Medium: Print
- Language: English
- Citation (JAMA): Boone Josh D, Balasuriya Udeni B, Karaca Kemal, et al. Recombinant Canarypox Virus Vaccine Co-expressing Genes Encoding the Vp2 and Vp5 Outer Capsid Proteins of Bluetongue Virus Induces High Level Protection in Sheep.. Vaccine Jan 2007;25:672-8
Abstract
We describe the development and preliminary characterization of a recombinant canarypox virus vectored vaccine for protective immunization of ruminants against bluetongue virus (BTV) infection. Sheep (n=6) immunized with recombinant canarypox virus vector (BTV-CP) co-expressing synthetic genes encoding the two outer capsid proteins (VP2 and VP5) of BTV serotype 17 (BTV-17) developed high titers (40-160) of virus-specific neutralizing antibodies and were resistant to challenge with a field strain of BTV-17. In contrast, sheep (n=5) immunized with a commercial recombinant canarypox virus vector expressing the E and preM genes of West Nile virus were seronegative to BTV and developed pyrexia, lymphopenia, and extended, high-titered viremias following challenge exposure to the field strain of BTV-17. These data confirm that the BTV-CP vaccine may be useful for the protective immunization of ruminants against bluetongue, and it may avoid the problems inherent to live-attenuated (LA) BTV vaccines.
Mesh Headings (Keywords): Animals, Bluetongue, Bluetongue virus, Canarypox virus, Capsid Proteins, Female, Gene Expression Regulation, Viral, Male, Sheep, Time Factors, Viral Vaccines
Check for Full Text / PubMed Unique Identifier (PMID): 17059856
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.