Early Resolution of Herpes Simplex Virus Type 2 Infection of the Murine Genital Tract Involves Stimulation of Genital Parenchymal Cells by Gamma Interferon.
From: Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0436, USA.
Journal of virology
- Publish Date: Jan 2007
- ISSN: 0022-538X
- Volume: 81
- Issue: 1
- Pages: 423-6
- Medium: Print
- Language: English
- Citation (JAMA): Bird Melanie D, Chu Chin-Fun, Johnson Alison J, et al. Early Resolution of Herpes Simplex Virus Type 2 Infection of the Murine Genital Tract Involves Stimulation of Genital Parenchymal Cells by Gamma Interferon.. J. Virol. Jan 2007;81:423-6
Abstract
Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-gamma). Transfer of activated CD8+ T cells to irradiated C57BL/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-gamma receptor (IFN-gammaR). Early virus clearance was demonstrated in radiation chimeras in which IFN-gammaR expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-gammaR expression and chimeras expressing IFN-gammaR only on hematopoietic cells. Together, these results suggest that early IFN-gamma-mediated protection was manifested mainly by stimulation of genital parenchymal cells.
Mesh Headings (Keywords): Animals, Female, Herpes Genitalis, Herpesvirus 2, Human, Interferon Type II, Mice, Mice, Inbred C57BL, Receptors, Interferon, T-Lymphocytes, Vagina
Check for Full Text / PubMed Unique Identifier (PMID): 17065206
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