Microdamage and Bone Mechanobiology.
From: Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland. tclee@rcsi.ie
Technology and health care : official journal of the European Society for Engineering and Medicine
- Publish Date: 2006
- ISSN: 0928-7329
- Volume: 14
- Issue: 4-5
- Pages: 359-65
- Medium: Print
- Language: English
- Citation (JAMA): Lee T C, O'Brien F J, Gunnlaugsson T, et al. Microdamage and Bone Mechanobiology.. 2006;14:359-65
Abstract
Mechanobiology is concerned with the relationships between mechanical forces and biological processes. Bone adapts to altered mechanical loading by modelling and remodelling. Microdamage is a stimulus for adaptation as shown by a sheep overload model. If microdamage accumulates it leads to fracture failure, notably in osteoporosis. Detection methods, based on chelating fluorochromes and radiopaque agents, will enable microdamage to be quantified and, along with bone mass, aid in fracture prediction and prevention. Mechanobiological principles can be utilised to create tissue engineered bone grafts in cases of bone loss due to trauma, malignancy or resorption.
Mesh Headings (Keywords): Adaptation, Physiological, Biomechanics, Bone Density, Bone Remodeling, Bone and Bones, Compressive Strength, Connective Tissue, Fractures, Bone, Fractures, Stress, Humans, Models, Biological, Osteoporosis, Stress, Mechanical, Tissue Engineering, Weight-Bearing
Check for Full Text / PubMed Unique Identifier (PMID): 17065757
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