The First Potassium Channel Toxin from the Venom of the Iranian Scorpion Odonthobuthus Doriae.
From: Laboratory of Toxicology, University of Leuven, Onderwijs and Navorsing II, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium.
FEBS letters
- Publish Date: Nov 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 26
- Pages: 6254-8
- Medium: Print
- Language: English
- Citation (JAMA): Abdel-Mottaleb Yousra, Clynen Elke, Jalali Amir, et al. The First Potassium Channel Toxin from the Venom of the Iranian Scorpion Odonthobuthus Doriae.. FEBS Lett. Nov 2006;580:6254-8
Abstract
The very first member of K(+) channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as alpha-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K(+) channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183+/-3 nM but did not affect any of the other channels.
Mesh Headings (Keywords): Animals, Electrophysiology, Inhibitory Concentration 50, Oocytes, Potassium, Potassium Channels, Scorpion Venoms, Sequence Alignment, Transfection, Xenopus laevis
Check for Full Text / PubMed Unique Identifier (PMID): 17070524
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