Unravelling the Complexities of the Nf-kappab Signalling Pathway Using Mouse Knockout and Transgenic Models.
From: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. gerondakis@wehi.edu.au
Oncogene
- Publish Date: Oct 2006
- ISSN: 0950-9232
- Volume: 25
- Issue: 51
- Pages: 6781-99
- Medium: Print
- Language: English
- Citation (JAMA): Gerondakis S, Grumont R, Gugasyan R, et al. Unravelling the Complexities of the Nf-kappab Signalling Pathway Using Mouse Knockout and Transgenic Models.. Oncogene Oct 2006;25:6781-99
Abstract
The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-kappaB pathway, namely the IkappaB kinase subunits (IKKalpha, IKKbeta and NEMO), the IkappaB proteins (IkappaBalpha, IkappaBbeta, IkappaBvarepsilon and Bcl-3) and the five NF-kappaB transcription factors (NF-kappaB1, NF-kappaB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.
Mesh Headings (Keywords): Animals, Female, Male, Mice, Mice, Knockout, Mice, Transgenic, Models, Animal, NF-kappa B, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 17072328
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