Nuclear Factor-kappab and Inhibitor of Kappab Kinase Pathways in Oncogenic Initiation and Progression.
From: Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
Oncogene
- Publish Date: Oct 2006
- ISSN: 0950-9232
- Volume: 25
- Issue: 51
- Pages: 6817-30
- Medium: Print
- Language: English
- Citation (JAMA): Bassères D S, Baldwin A S, et al. Nuclear Factor-kappab and Inhibitor of Kappab Kinase Pathways in Oncogenic Initiation and Progression.. Oncogene Oct 2006;25:6817-30
Abstract
Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-kappaB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-kappaB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-kappaB. Additionally, the effects of NF-kappaB activation in tumors relative to cancer therapy are also discussed.
Mesh Headings (Keywords): Animals, Cell Transformation, Neoplastic, Genes, Tumor Suppressor, Humans, I-kappa B Kinase, NF-kappa B
Check for Full Text / PubMed Unique Identifier (PMID): 17072330
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