Cross-talk Between Nuclear Receptors and Nuclear Factor Kappab.
From: Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Molecular Biology, Ghent University, Gent, Belgium. karolien.debosscher@ugent.be
Oncogene
- Publish Date: Oct 2006
- ISSN: 0950-9232
- Volume: 25
- Issue: 51
- Pages: 6868-86
- Medium: Print
- Language: English
- Citation (JAMA): De Bosscher K, Vanden Berghe W, Haegeman G, et al. Cross-talk Between Nuclear Receptors and Nuclear Factor Kappab.. Oncogene Oct 2006;25:6868-86
Abstract
A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
Mesh Headings (Keywords): Animals, Hormones, Humans, NF-kappa B, Receptor Cross-Talk, Receptors, Cytoplasmic and Nuclear, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 17072333
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